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. 2020 Jul 23;10:12340. doi: 10.1038/s41598-020-69298-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Percentages of the 73 textural features showing ICCs and CCCs values > 0.8 depending on the intensity normalization and the discretization method. (A) FBN T1w-gd, (B) FBN T2w-flair, (C) FBS T1w-gd, (D) FBS T2w-flair. FBN fixed bin number (relative discretization), FBS fixed bin size (absolute discretization), ICC intra-class correlation coefficient, CCC cross correlation coefficient. In (A) and (B), the No Normalization, WhiteStripe and Z-Score line plots are confounded. In (C) and (D), the No Normalization, WhiteStripe and Z-Score line plots are separated.