Skip to main content
. 2020 Jul 11;2020:6320514. doi: 10.1155/2020/6320514

Table 8.

Outcomes of RCTs that evaluated G-CSF safety and effectiveness.

Ref Type of growth factor Wound closure Mean time to heal in treatment groups Mechanism mentioned as complete healing Confounders Further outcomes
Granulation tissue Reepithelialization Sex Baseline HbA1c Wound size Offloading Recurrence rate Amputation rate
[25] G-CSF G-CSF therapy was associated with earlier eradication of pathogens from the infected (p = 0 · 02), quicker resolution of cellulitis (p = 0 · 03), shorter hospital stays (p = 0 · 02), and a shorter duration of intravenous antibiotic (p = 0 · 02). Neutrophil superoxide production was higher in the G-CSF-treated group (p < 0 · 0001) NM NM NM NM NM NM NM NM 2 cases in the placebo group
[28] G-CSF At the 3- and 9-week assessments, no significant differences in terms of complete closure of the ulcer without signs of underlying bone infection NM NM NM NM NM NM NM NM 15% in the G-CSF group and 45% in the control group. p = 0.03
[26] G-CSF No foot ulcer had completely healed at the end of the study. Patients who received G-CSF did not have an earlier resolution of clinically defined cellulitis (p = 0.57). The ulcer volume, was reduced by 59% in G-CSF and by 35% in placebo patients (p = 0.0005) NM NM NM NM NM NM NM NM 2 cases in total from both groups
[27] G-CSF No significant differences for duration of hospitalization, duration of parenteral antibiotic administration, time to resolution of infection, and need for amputation NM NM NM NM NM NM NM NM 13.3% in the treatment group and 20% in the placebo group. p > 0.05

G-CSF: granulocyte colony-stimulating factor; Y: yes; N: no; NM: not mentioned.