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The chemical structure of lead compounds. A) The structure of BAs and their derivatives, which acts upon FXR and FATP5 both as highlighted in Table 2. B-I) and B-II) The non-steroidal compounds for FXR and FATP5, respectively. We here showed the molecules in advance phases for FXR. For FATP5 only those molecules are picked which have substantially potent and can be used for lead discovery.
