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The regulation of key targets in in-vivo studies. The effective level of target genes involved in BA synthesis and fatty acid uptake. The expression level of these genes is studied for FATP5 and the same has been evaluated against FXR, too.
| Changes in Gene Expression | FXR (KO*) | FXR (CA) | FATP5 (KO) | References |
|---|---|---|---|---|
| cyp7a1 | Up | Down | Up | (9,48,60,74) |
| SHP | Down | Up | Down | |
| NTCP | Up | Down | Up | |
| BSEP | Down | Up | Up | |
| OATP | Up | No change | No change |
