Table 1.
The top 20 candidate ACE2 agonists
| Name | Function | CMap score |
|---|---|---|
| Cytochalasin-d | Actin polymerization inhibitor, actin stabilizer | 98.4 |
| Flubendazole | Microtubule inhibitor, anthelmintic drug | 98.2 |
| Triciribine* | DNA synthesis inhibitor, AKT inhibitor, HIV inhibitor | 97.8 |
| Rigosertib* | Multi-kinase inhibitor, cell cycle inhibitor, apoptosis inducer | 97.7 |
| Prostratin | NFkB activator, protein kinase activator, HIV inhibitor | 95.2 |
| HG-5-88-01 | Protein kinase inhibitor | 94.7 |
| Quinoclamine | Algicide | 94.4 |
| HU-211 | Glutamate receptor antagonist, neuroprotective, antioxidant | 93.9 |
| CS-1657 | PARP inhibitor | 93.6 |
| Deforolimus | mTOR inhibitor, angiogenesis inhibitor, immunosuppressant | 93.1 |
| Kinetin-riboside* | Apoptosis inducer, anti-proliferative agent | 91.8 |
| Vinorelbine | Mitosis inhibitor, microtubule inhibitor, apoptosis inducer | 91.6 |
| Triamcinolone* | Corticosteroid hormone receptor agonist, anti-inflammatory agent | 91.3 |
| Perospirone | Dopamine receptor antagonist, antipsychotic agent | 91.2 |
| OMDM-2 | Anandamide uptake inhibitor | 91.1 |
| Eicosatetraynoic-acid | Cyclooxygenase inhibitor, Arachidonic acid uptake inhibitor | 91.0 |
| Cilomilast* | Phosphodiesterase inhibitor, for respiratory disorders (COPD) | 90.9 |
| BRD-K28680267 | Cholecystokinin (CCK) receptor inhibitor | 90.7 |
| Desoxycortone | Mineralocorticoid receptor agonist | 90.7 |
| Phensuximide | Anticonvulsant | 89.1 |
*Represents the available compounds for subsequent validation experiments