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Effect of SAL and/or CEL on Panc-1 cells in 3D cultures. Panc-1 cells were seeded in Matrigel in a 12-well plate (1 mL/well) and treated with SAL and/or CEL once every other day for 10 days. Representative micrographs of Panc-1 3D cell cultures of control cells (A), SAL-treated (B), CEL-treated (C), and combination-treated (D) groups are shown. Data are expressed as the mean ± SD from three separate experiments. aP<0.001 vs. treatment with SAL or CEL alone.
