Table 3.
AUC/MIC and CMAX/MIC Univariate Generalized Logistic Regression for Treatment Failure (Left Columns) and Cox-Proportional Hazard for Recurrence (Right Columns)
| Treatment Failure | Recurrence | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | OR | 2.5% | 97.5% | P-value | N | OR | 2.5% | 97.5% | P-value | |
| MIC adjusted pharmacokinetic covariates | ||||||||||
| log(Isoniazid AUC0–24/MIC) | 47 | 0.01740 | 1.25e-04 | 0.2840 | .001410 | 42 | 4.07000 | 1.44e-01 | 115 | .410 |
| log(Isoniazid CMAX/MIC) | 47 | 0.00040 | 0.00e+00 | 0.0833 | .000293 | 42 | 9.19000 | 1.49e-02 | 5660 | .499 |
| log(Rifampicin AUC0–24/MIC) | 47 | 0.25100 | 3.99e-02 | 1.3000 | .099900 | 42 | 8.12000 | 4.41e-01 | 149 | .159 |
| log(Rifampicin CMAX/MIC) | 47 | 0.37300 | 6.18e-02 | 2.0500 | .248000 | 42 | 3.16000 | 5.57e-02 | 179 | .577 |
| log(Ethambutol AUC0–24/MIC) | 47 | 0.34200 | 2.85e-02 | 4.0600 | .377000 | 42 | 34.60000 | 7.60e-03 | 157000 | .410 |
| log(Ethambutol CMAX/MIC) | 47 | 0.23900 | 2.01e-02 | 2.6000 | .227000 | 42 | 1.30000 | 9.43e-03 | 179 | .917 |
| Pharmacokinetic covariates | ||||||||||
| log(Isoniazid AUC0–24) | 47 | 0.08300 | 2.01e-03 | 1.4000 | .089500 | 42 | 2.34000 | 4.63e-02 | 118 | .671 |
| log(Isoniazid CMAX) | 47 | 0.00132 | 5.00e-07 | 0.7050 | .037800 | 42 | 0.72100 | 1.57e-05 | 33200 | .952 |
| log(Rifampicin AUC0–24) | 47 | 0.35700 | 7.33e-03 | 5.0600 | .499000 | 42 | 7.54000 | 2.68e-01 | 212 | .235 |
| log(Rifampicin CMAX) | 47 | 1.79000 | 2.18e-02 | 62.3000 | .770000 | 42 | 1.50000 | 1.47e-03 | 1530 | .909 |
| log(Ethambutol AUC0–24) | 47 | 0.01630 | 4.20e-06 | 9.6900 | .220000 | 42 | 12.90000 | 2.24e-04 | 742000 | .648 |
| log(Ethambutol CMAX) | 47 | 0.00267 | 8.00e-07 | 1.1500 | .056000 | 42 | 0.00015 | 0.00e+00 | 495 | .250 |