Fig. 1.

Serial biomarker levels before closure (baseline) and 1 day, 3 months and 1 year after percutaneous ASD closure in adults. X-axis are on the 2-log scale. Delta (Δ) represents the median of the difference in the biomarker level before and one day ASD after closure in. P-value represents level of significance of the paired t-test. Abbreviations: NT-proBNP = N-terminal pro B type natriuretic peptide, GDF-15 = growth differentiation factor 15, RDW = red cell distribution width, hs-CRP = high sensitive c-reactive protein. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)