Individual biomarker trajectories of NT-proBNP, hs-troponin T, hs-CRP, RDW, GDF-15 and galectin-3 stratified according to age at ASD closure. gray lines represent individual biomarker trajectories over time. Square represents the median biomarker level, together with the 25th and 75th percentile (indicated by the error bars). Abbreviations: NT-proBNP = N-terminal pro B type natriuretic peptide, GDF-15 = growth differentiation factor 15, RDW = red cell distribution width, hs-CRP = high sensitive c-reactive protein. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)