Table 2.
Correlations between biomarker levels and baseline clinical characteristics as well as ASD closure related characteristics.
| NT-proBNP | hs-TnT | Hs-CRP | RDW | GDF-15 | Gal-3 | |
|---|---|---|---|---|---|---|
| r | r | r | r | r | r | |
| Clinical Characteristics | ||||||
| Age at closure | 0.51*** | 0.74*** | 0.25 | 0.18 | 0.75*** | 0.30* |
| Women | 0.16 | −0.55*** | 0.07 | 0.10 | −0.09 | −0.09 |
| Body mass index | 0.14 | 0.213 | 0.26 | 0.37** | 0.12 | 0.29 |
| Systolic blood pressure | 0.09 | 0.45** | 0.11 | −0.30* | 0.41** | −0.09 |
| NYHA class | 0.37* | 0.25 | 0.21 | −0.03 | 0.31* | −0.12 |
| Cardiac medication use | 0.52*** | 0.63*** | 0.36* | 0.27 | 0.57*** | 0.47** |
| Hypertension | 0.36* | 0.48** | 0.25 | 0.20 | 0.41** | 0.06 |
| Atrial fibrillation | 0.44** | 0.54*** | 0.19 | 0.40** | 0.40** | 0.26 |
| Electrocardiography | ||||||
| Heart rate | −0.03 | 0.00 | 0.06 | −0.11 | 0.01 | −0.27 |
| PR interval † | 0.07 | 0.40* | 0.11 | 0.07 | 0.28 | 0.29 |
| QRS duration | 0.01 | 0.39** | 0.01 | 0.03 | 0.25 | 0.21 |
| Echocardiography | ||||||
| LV end-diastolic dimension | 0.05 | 0.17 | −0.19 | 0.19 | 0.09 | 0.01 |
| E/E’ | 0.08 | 0.13 | 0.41* | −0.04 | 0.09 | −0.23 |
| E/A | 0.12 | −043* | 0.00 | 0.817 | −0.35 | 0.03 |
| Left atrial dimension | 0.54*** | 0.48** | 0.15 | 0.41** | 0.47** | 0.38** |
| Right atrial area | 0.45** | 0.35* | 0.01 | 0.31* | 0.25 | 0.18 |
| RVED area | 0.20 | 0.27 | 0.05 | 0.28 | 0.16 | 0.30* |
| RVED basal diameter | −0.03 | 0.09 | 0.15 | −0.01 | −0.01 | 0.08 |
| RVED apex to base length | −0.26 | 0.08 | −0.24 | −0.15 | −0.011 | −0.010 |
| RV fractional area change | −0.20 | −0.19 | 0.19 | −0.00 | −0.21 | 0.05 |
| TAPSE | −0.34* | −0.18 | 0.14 | −0.10 | −0.17 | 0.00 |
| Right atrial pressure of 8 mmHg | 0.47** | 0.29 | 0.09 | 0.34* | 0.30 | 0.18 |
| RV systolic pressure, mmHg | 0.55*** | 0.47** | 0.37* | 0.21 | 0.47** | 0.29 |
| Hemodynamics | ||||||
| Right atrial pressure | 0.26 | −0.05 | −0.04 | 0.43** | 0.16 | 0.15 |
| Mean PAP | 0.49** | 0.37* | 0.27 | 0.37* | 0.21 | 0.29 |
| Procedural characteristics | ||||||
| Diameter of ASD, balloon | 0.27 | 0.04 | 0.26 | 0.31 | −0.01 | 0.23 |
| Diameter of ASD, echo | 0.03 | −0.02 | −0.25 | 0.08 | −0.02 | 0.04 |
| Device size | 0.05 | 0.07 | 0.11 | −0.16 | 0.14 | 0.07 |
| Device size, bsa indexed | 0.08 | −0.05 | 0.13 | −0.19 | 0.14 | 0.14 |
Table legend: Significant correlations are printed in bold with the corresponding level of significance shown by the number of asterisks (* p-value < 0.05, **p-value < 0.01, *** p-value < 0.001).
Abbreviations: NYHA = New York Heart Association, RBBB = right bundle branch block, LV = left ventricular, RV = right ventricular, RVED = right ventricular end-diastolic, TAPSE = tricuspid annular plane systolic excursion, PAP = pulmonary artery pressure, NT-proBNP = N-terminal pro-B natriuretic peptide, hs-TnT = high sensitivity troponin-T, hs-CRP = high sensitivity C-reactive protein, RDW = red cell distribution width, GDF-15 = growth differentiation factor-15, gal-3 = galectin-3.