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. 2020 Jul 16;10:1177. doi: 10.3389/fonc.2020.01177

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Copyright © 2020 Sanchez-Martin, Serapian, Colombo and Rasola.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HSP90 and TRAP1 chaperones are involved in several pro-neoplastic biological processes. Many clients of HSP90 and TRAP1 (in yellow and orange, respectively) are proteins that regulate key tumorigenic processes. GLUT1, glucose transporter 1; SDH, succinate dehydrogenase; COX, cytochrome c oxidase; VEGF, vascular endothelial growth factor; MMP2, matrix metallopeptidase 2; HIF1α, hypoxia-inducible factor 1-alpha; hTERT, human telomerase reverse transcriptase; ERK 1/2, extracellular signal-regulated kinase 1/2; HER2, human epidermal growth factor receptor 2; ALK, anaplastic lymphoma kinase; CDK, cyclin-dependent kinase; CyP-D, cyclophilin D; Epha2, ephrin type-A receptor 2; IFIT3; Interferon induced protein with tetratricopeptide repeats 3.