Figure 6.

Adverse Effects of CD28- and 4-1BB-Based CAR-T Cells

(A and B) Analysis of cytokine levels in the peripheral blood of patients after infusion of CD28- (A) and 4-1BB-based CAR-T cells (B). (C) Ratio of different cytokine release syndrome (CRS) grades induced by both CAR-T types. (D) Comparison of the CRS emergence time between the two treatment groups. (E) Comparison of the CRS duration time between the two treatment groups. (F) Number of patients with neurotoxicity after treatment with both CAR-T types. The error bars represent the standard derivation; ns, not significant.