Table 2.

Detected methQTLs based on 1 MB neighboring SNPs of CpGs in gene DUSP22 between genetic and epigenetic association studies with asthma.

Gene	CpG	SNPs	Gtypea	DNAm mean	DNAm SD	Effects (95% CIb)	P value	PFDR c
DUSP22	cg01516881	rs10418525	AA	−6.2	0.056	—	2.25 × 10−5	2.77 × 10−2
			AG	−1.1	1.36	5.1; (3.2, 7.0)
			GG	−1.8	2.91	4.3; (2.5, 6.2)
	cg01516881	rs10423498	AA	−2.68	4.45	—	5.61 × 10−5	2.77 × 10−2
			AG	−0.97	0.49	1.7; (0.61, 2.80)
			GG	−4.77	7.73	−2.1; (−3.87, −0.31)
	cg01516881	rs11706690	AA	−1.7	3.8	—	6.50 × 10−5	2.77 × 10−2
			AC	−1.2	1.1	0.51; (−0.75, 1.77)
			CC	−4.5	5.1	−2.79; (−4.39, −1.19)
	cg03624871	rs10118798	AA	0.72	0.14	—	4.78 × 10−5	2.92 × 10−2
			AG	1.80	0.27	1.08; (0.61, 1.56)
			GG	1.68	NA	0.97; (0.17, 1.76)
	cg03624871	rs1410968	AA	0.72	0.14	—	4.78 × 10−5	2.92 × 10−2
			AG	1.80	0.27	1.08; (0.61, 1.56)
			GG	1.68	NA	0.97; (0.17, 1.76)
	cg11235426	rs11706690	AA	−1.5	0.95	—	1.74 × 10−5	2.23 × 10−2
			AC	−1.4	0.43	0.097; (−0.55, 0.75)
			CC	−3.3	0.93	−1.723; (−2.55, −0.90)
	cg22949951	rs7840893	AG	1.98	NA	—	2.04 × 10−5	1.32 × 10−2
			GG	0.55	0.084	−1.4; (−2.0, −0.84)
	cg22949951	exm2216266	AA	0.55	0.084	—	2.04 × 10−5	1.32 × 10−2
			GG	1.98	NA	1.43; (0.84, 2.03)
	cg24325581	rs4797173	AA	4.1	NA	—	3.95 × 10−5	4.65 × 10−2
			AG	3.1	0.14	−1.0; (−1.6, −0.43)
			GG	2.8	0.039	−1.3; (−1.9, −0.72)
	cg24325581	rs12970203	AA	2.8	0.046	—	1.03 × 10−4	4.91 × 10−2
			AC	3.1	0.219	0.29; (0.066, 0.52)
			CC	4.1	NA	1.24; (0.661, 1.82)
	cg24325581	rs34383812	AA	3.6	0.614	—	1.51 × 10−4	4.91 × 10−2
			AG	2.9	0.051	−0.70; (−1.1, −0.35)
			GG	2.7	0.044	−0.91; (−1.3, −0.52)
	cg24325581	rs910858	AA	2.8	0.051	—	2.27 × 10−4	4.91 × 10−2
			AG	2.9	0.071	0.017; (−0.18, 0.22)
			GG	3.6	0.500	0.806; (0.45, 1.17)
	cg24325581	rs10409912	AA	2.8	0.05	—	2.36 × 10−4	4.91 × 10−2
			AG	3.1	0.18	0.24; (0.025, 0.46)
			GG	4.1	NA	1.24; (0.641, 1.83)
	cg24325581	rs7236111	AA	2.8	0.047	—	2.50 × 10−4	4.91 × 10−2
			AG	3.0	0.127	0.21; (0.012, 0.4)
			GG	3.7	0.237	0.93; (0.501, 1.4)

Abbreviations: ANOVA, analysis of variance; CpG, 5′-C-phosphate-G-3′; DNAm, DNA methylation; FDR, false discovery rate; methQTLs, methylation quantitative loci; NA, not applicable; SNPs, single-nucleotide polymorphisms.

^aGtype: genotype; the first genotype for each SNP is the reference in the ANOVA test.

^b95% CI: 95% confidence interval of the effects. Also, “—” indicates the reference group.

^cP_FDR: P values after adjusting for multiple testing by controlling the FDR of 0.05 based on the P values from ANOVA tests for each gene.