Figure 3.

Kaplan–Meier curves showing the OS of patients with sorafenib-resistant advanced HCC treated with apatinib, stratified into subgroups. (A) The median OS was 16.0 months (95% CI: 13.9, 18.1) for patients with a liver tumor load <50% and 5.0 months (95% CI: 4.3, 5.7) for patients with a liver tumor load ⩾50% (p < 0.001). (B) The median OS was 15.0 months (95% CI: 12.8, 17.2) for patients with extrahepatic spread and 5.0 months (95% CI: 4.2, 5.8) for patients without extrahepatic spread (p < 0.001).

ES, extrahepatic spread; HCC, hepatocellular carcinoma; mOS, median overall survival.