Table 3.

Univariate and multivariate analysis of prognostic factors in the apatinib group.

Variable	Univariate analysis		Multivariate analysis
	Median OS, months (95% CI)	p value	Hazard ratio (95% CI)	p value
Liver tumor load		<0.001		<0.001
<50%	16.0 (13.9–18.1)		Ref
⩾50%	5.0 (4.3–5.7)		3.653 (2.047–5.965)
Number of tumors		0.029		0.087
>5	6.0 (4.8–7.2)		Ref
1–5	13.0 (10.1–15.9)		0.326 (0.090–1.175)
PVTT		<0.001		0.130
Absent	12.0 (3.1–16.9)		Ref
Present	6.0 (4.3–7.7)		2.935 (0.728–11.835)
Extrahepatic spread		<0.001		0.003
Present	15.0 (12.8–17.2)		Ref
Absent	5.0 (4.2–5.8)		0.303 (0.231–0.778)
Child-Pugh		0.001		0.088
A	7.0 (6.1–7.9)		Ref
B	3.5 (2.0–5.0)		2.392 (0.879–6.508)
Ascites		0.002		0.091
Absent	7.0 (6.0–8.0)		Ref
Present	4.0 (3.4–4.6)		2.208 (0.882–5.525)

CI, confidence interval; OS, overall survival; PVTT, portal vein tumor thrombosis.