TABLE 1.

Chlorpromazine, while without effect at 5-HT_1A, 5-HT₃, and 5-HT₄ receptors, is a 5-HT_2A, 5-HT_2C, 5-HT₆, and 5-HT₇ antagonist and thus theoretically—at least from a serotonergic perspective—does not display the ideal required profile for a vagus activator. Affinities for the dopaminergic receptors are also provided.

	5-HT (Ki nM); antagonist
	1A	2A	2C	3	4	6	7
Chlorpromazine	800+	10–15	15–25	600+	Not available	5	20
	Dopamine (Ki nM); antagonist
	1	2	3	4	5
Chlorpromazine	6–96	2–12	2–10	8–56	Not available

(Kuoppamäki et al., 1995; Yonemura et al., 1998; Glennon, 2003; Kusumi et al., 2015).