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. 2020 Jul 23;11:3690. doi: 10.1038/s41467-020-17538-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Orthogonal views of the cryo-EM density contoured at 7.0 σ. Each subunit is uniquely colored. b Orthogonal views of the MSL1 structure. Transmembrane helices TM2-5, the C-terminal extramembrane domain located in the mitochondrial matrix, and the dimension of the channel are indicated. c A single subunit of MSL1 is shown in cartoon representation with TM helices (TM2-4 in green and TM5 in purple) and extramembrane domains (cyan) indicated. Cryo-EM density contoured at 6.5 σ is shown in blue mesh.