Table 3.
Treatment patterns | 12 months pre-PP1M switch (n = 493) | 12 months post-PP1M switch (n = 493) |
---|---|---|
AP use | ||
Any oral APs | 493 (100.0)* | 342 (69.4)* |
Atypical oral APs | 493 (100.0)* | 334 (67.8)* |
Any LAI APs | 125 (25.4)* | 493 (100.0)* |
Atypical LAI APs | 93 (18.9)* | 493 (100.0)* |
Antidepressants | 343 (69.6)* | 328 (66.5)* |
Anxiolytics | 270 (54.8)* | 266 (54.0)* |
Mood stabilizers | 261 (52.9)* | 246 (49.9)* |
PDC† | ||
Any agent | 0.6 (0.3)‡ | 0.7 (0.3)‡§ |
≥80% | 135 (27.4)* | 265 (53.8)*§ |
RIS/PALI | 0.4 (0.3)‡ | 0.2 (0.3)‡§ |
≥80% | 54 (11.0)* | 22 (4.5)*§ |
PP1M | – | 0.5 (0.3)‡ |
≥80% | – | 133 (27.0)* |
MPR|| | ||
Any agent | 0.7 (0.3)‡ | 0.9 (0.3)‡§ |
≥80% | 230 (46.7)* | 366 (74.2)*§ |
RIS/PALI | 0.4 (0.4)‡ | 0.2 (0.3)‡§ |
≥80% | 109 (22.1)* | 64 (13.0)*§ |
PP1M | – | 0.6 (0.4)‡ |
≥80% | – | 177 (35.9)* |
AP = antipsychotic; LAI = long-acting injectable; MPR = medication possession ratio; PDC = proportion of days covered.
Value is presented as n (%).
Defined as the sum of nonoverlapping days of supply divided by a fixed period (ie, 6 or 12 months) and medication possession ratio. Adherence to therapy was defined as PDC ≥80%.
Value is mean (SD).
P < 0.05.
Defined as the sum of the days of supply during exposure divided by the duration of exposure to therapy. Adherence to therapy was defined as MPR ≥80%.