The upper-left numbers indicate the round. The top 90 dominant
genotypes of each RNA species were plotted for each round. A point
represents each genotype. The colors of points are consistent with
Figure 2, the host
(blue), parasite-α (red), -β (green), and -γ (purple). A star in
each figure represents the most frequent genotype of the host
(blue), parasite-α (red), -β (green), and -γ (purple). Black lines
connect pairs of points one Hamming distance apart in the same RNA
species. A broken line connects a pair of points zero Hamming
distance apart in the different RNA species, ignoring the large
deletion, which represent a plausible generation route of each
parasite. Colors of the broken lines correspond to the host and
parasite-α (red), the host and parasite-β (green), and the host and
parasite-γ (purple). Parasite-α is not shown in the round-39, 50,
and 65 because they could not have been recovered and sequenced.