Table 3. Mean Absolute Difference in Gleason Pattern Quantitation Relative to Subspecialistsa.
| Gleason pattern | No. | Subspecialist discordance, % (95% CI) | |
|---|---|---|---|
| Deep learning system | Pathologist | ||
| 3 (Tumor-containing specimens) | 498 | 9.2 (8.0-10.5)b | 14.0 (12.4-15.6) |
| 4 (Tumor-containing specimens) | 498 | 10.0 (8.6-11.2)b | 16.3 (14.6-18.1) |
| 5 (Tumor-containing specimens) | 498 | 1.5 (0.9-2.1)b | 3.2 (2.2-4.3) |
| 4 (Grade group 2 specimens only) | 122 | 12.0 (10.4-13.6)b | 22.0 (19.6-24.6) |
a
Gleason pattern quantitation reflects the proportion of tumor in each biopsy specimen that is characterized as each Gleason pattern. The mean absolute differences in Gleason pattern quantitation are measured against the mean of subspecialist quantitation results for all tumor-containing biopsy specimens (rows 1-3) or grade group 2 biopsy specimens only (row 4).
b
Lower absolute differences (higher agreement rate in Gleason pattern quantitation).