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. 2020 Apr 30;13(2):237–245. doi: 10.15283/ijsc20001

Fig. 3.

Fig. 3

Knockdown of SOCS1 reverses the inhibition of plasma cell formation by MSCs. B cells were stimulated with LPS (A), LPS/IL4 (B), LPS/TGFβ (C) for 23 hours and then co-cultured by adding MSC/CTLsh or MSC/SOCS1sh at a ratio of 1：10. After two days of co-cultivation, B cells were harvested, labeled with anti-B220 and anti-CD138 antibodies and analyzed for plasma cell formation by flow cytometry. Data were representative of three independent experiments. *p<0.05. Note: CTLsh, MSC/CTLsh; SOCS1sh, MSC/SOCS1sh.