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Overexpression of p21 interfered with the expression of hematopoiesis-related genes in co-cultures with AGM-S3 cells. p21/hESCs co-cultures were treated with DOX from D0. qRT-PCR analyses at D4 revealed that hematopoiesis-related genes, including GATA1, GATA2, vWF, and LOM2, were down-regulated. Expression of CD34+ was not influenced, but RUNX1b/c was up-regulated, potentially causing the inhibitory effects of p21 on hematopoiesis.
