Table 2.
Multivariate analysis for EFS and OS
| Expression | Methylation | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variables | EFS | OS | EFS | OS | ||||||||||||
| HR | Lower 95% | Upper 95% | P-value | HR | Lower 95% | Upper 95% | P-value | HR | Lower 95% | Upper 95% | P-value | HR | Lower 95% | Upper 95% | P-value | |
| Age (≥ 60 vs < 60 years) |
2.5725 | 1.1378 | 5.8163 | 0.0232 | 3.2294 | 1.5521 | 6.7192 | 0.0017 | 3.0966 | 1.3541 | 7.0816 | 0.0074 | 4.0511 | 1.933 | 8.4901 | 0.0002 |
| BM_BLAST (≥ 70% vs < 70%) |
0.681 | 0.2939 | 1.5779 | 0.3702 | 1.3341 | 0.6107 | 2.9143 | 0.4697 | 0.7641 | 0.3383 | 1.7261 | 0.5176 | 1.0605 | 0.5395 | 2.0847 | 0.8647 |
| WBC (≥ 30 vs < 30 × 109/L) |
1.231 | 0.5412 | 2.8001 | 0.6202 | 1.1855 | 0.5588 | 2.5154 | 0.6574 | 1.4907 | 0.6326 | 3.5131 | 0.3613 | 1.3226 | 0.6549 | 2.6713 | 0.4356 |
| PB_BLAST (≥ 50% vs < 50%) |
2.0875 | 0.8734 | 4.9891 | 0.0978 | 1.5356 | 0.6743 | 3.4974 | 0.307 | 1.5147 | 0.649 | 3.535 | 0.337 | 1.3654 | 0.6393 | 2.916 | 0.4212 |
| DNMT3A (Mutation vs WT) |
2.736 | 1.2195 | 6.1382 | 0.0146 | 1.8003 | 0.8665 | 3.7407 | 0.1151 | 2.2837 | 1.1137 | 4.6825 | 0.0242 | 1.71 | 0.9114 | 3.2081 | 0.0947 |
| NPM1 (Mutation vs WT) |
0.5736 | 0.2174 | 1.5137 | 0.2616 | 1.3132 | 0.5354 | 3.2207 | 0.5517 | 0.599 | 0.2089 | 1.7176 | 0.3403 | 0.7929 | 0.3359 | 1.8717 | 0.5964 |
| TET2 (Mutation vs WT) |
0.6495 | 0.24 | 1.7582 | 0.3957 | 0.3256 | 0.1025 | 1.0338 | 0.057 | 0.68 | 0.2459 | 1.8803 | 0.4574 | 0.339 | 0.1193 | 0.9632 | 0.0423 |
| FLT3 (Mutation vs WT) |
2.9251 | 1.1391 | 7.5116 | 0.0257 | 0.6255 | 0.2628 | 1.4886 | 0.2888 | 1.7359 | 0.6918 | 4.3555 | 0.24 | 0.8241 | 0.3677 | 1.8468 | 0.6384 |
| IDH2 (Mutation vs WT) |
0.5593 | 0.1634 | 1.915 | 0.3548 | 0.3661 | 0.1187 | 1.1294 | 0.0804 | 0.4727 | 0.1293 | 1.7287 | 0.2574 | 0.2552 | 0.0843 | 0.7723 | 0.0156 |
| IDH1 (Mutation vs WT) |
0.9 | 0.2315 | 3.4991 | 0.8792 | 0.3561 | 0.0934 | 1.3581 | 0.1306 | 1.3305 | 0.3742 | 4.731 | 0.6591 | 0.6212 | 0.1822 | 2.1174 | 0.4467 |
| RUNX1 (Mutation vs WT) |
2.1777 | 0.5549 | 8.5461 | 0.2646 | 2.1675 | 0.5606 | 8.3811 | 0.2622 | 2.8638 | 0.754 | 10.877 | 0.1223 | 2.4935 | 0.7737 | 8.0359 | 0.126 |
| NRAS (Mutation vs WT) |
0.5041 | 0.1199 | 2.12 | 0.35 | 0.2164 | 0.0429 | 1.0927 | 0.0639 | 0.2035 | 0.0503 | 0.8227 | 0.0255 | 0.3544 | 0.1113 | 1.1291 | 0.0793 |
| WT1 (Mutation vs WT) |
1.361 | 0.3113 | 5.951 | 0.6822 | 0.7724 | 0.1898 | 3.1428 | 0.7183 | 1.5361 | 0.4222 | 5.5886 | 0.5147 | 0.8738 | 0.2811 | 2.7162 | 0.8157 |
| CEBPA (Mutation vs WT) |
1.2394 | 0.3529 | 4.3533 | 0.7378 | 0.8825 | 0.2661 | 2.927 | 0.8381 | 1.1389 | 0.333 | 3.895 | 0.8357 | 0.6804 | 0.2248 | 2.0592 | 0.4956 |
| PTPN11 (Mutation vs WT) |
1.4844 | 0.3461 | 6.3668 | 0.595 | 2.1746 | 0.6486 | 7.2903 | 0.2082 | 1.6253 | 0.4457 | 5.9276 | 0.4619 | 2.2243 | 0.7319 | 6.7602 | 0.1587 |
| KRAS (Mutation vs WT) |
5.1838 | 1.0516 | 25.552 | 0.0432 | 1.4234 | 0.3101 | 6.5341 | 0.6498 | 2.0753 | 0.3629 | 11.866 | 0.4118 | 1.1431 | 0.2516 | 5.1927 | 0.8625 |
| ACTL10 (High vs Low) |
0.7691 | 0.3454 | 1.7126 | 0.5204 | 0.3975 | 0.1868 | 0.8458 | 0.0166 | 4.6053 | 2.1979 | 9.6495 | 5E-05 | 3.1101 | 1.646 | 5.8764 | 0.0005 |
BM_BLAST: Percentage of bone marrow blast cell; WBC: White blood cell of peripheral blood; PB_BLAST: Percentage of peripheral blood blast cell; Cox regression analysis.