Figure 4.

UQCRC2 suppressed GC cell proliferation in vivo. Xenograft tumor model was established in nude mice using UQCRC2-overexpressing GC cells (lenti-UQCRC2) and negative control cells. (n = 8 for each group). (A-D) Based on luciferase live-cell imaging, over-expression of UQCRC2 suppressed GC xenograft growth in nude mice. The volume and weight of xenograft and control cell growth were monitored. Data (mean ± SD, n = 8) were analyzed by Student's t-test; *P < 0.05, **P < 0.01. (E) The effect of UQCRC2 on cell metastasis was determined by Ki67 and hematoxylin and eosin staining of GC samples extracted from nude mice.