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. 2020 Jun 23;11(17):5042–5055. doi: 10.7150/jca.45553

Figure 5.

Figure 5

miR-370 targeted UQCRC2. (A) The microRNA.org online database was used to predict the miRNA targeting UQCRC2. (B) miR-370 expression levels in 30 GC tissue specimens and matched para-carcinoma tissue specimens were measured by qRT-PCR. **P < 0.01, relative to control. (C) Pearson's correlation analysis showed that miR-370 was inversely correlated with UQCRC2 mRNA levels. (D,E) UQCRC2 expression levels in SGC-7901 and MGC-803 cells transfected with a miR-370 inhibitor, a miR-370 mimic, or respective controls, were determined by qRT-PCR and western blotting. (F) SGC-7901 cells were co-transfected with miR-370 mimics and plasmids expressing wild-type (WT-UQCRC2) or mutant (MUT-UQCRC2) UQCRC2. Luciferase reporter assays were performed to analyze relative luciferase activity. Data are expressed as the mean ± SD. **P < 0.01, relative to the negative control mimic.