Skip to main content
. 2020 Jun 23;11(17):5042–5055. doi: 10.7150/jca.45553

Figure 7.

Figure 7

The miR-370/UQCRC2 axis in epithelial-mesenchymal transition. (A) The epithelial-mesenchymal transition (EMT) signal transduction pathway was estimated to be most positively correlated with EMT upon Gene Set Variation Analysis(GSVA). We set |t| > 5 as a cutoff value. (B) UQCRC2 and EMT marker protein expression was measured in SGC-7901 cells after transfection with a UQCRC2-expressing plasmid and miR-370 mimics or negative control (NC) constructs. GAPDH was used as the internal reference. Western blotting analyses of the expression of UQCRC2 and EMT markers in MGC-803 cells following miR-370 inhibitor or UQCRC2-specific siRNA transfection, relative to NC construct transfection. (C) Typical images of immunohistochemical staining of altered EMT hallmark proteins following UQCRC2 down-regulation.