Table 1.
The top 30 hub genes in PPI networks
| Up-regulated genes | Down-regulated genes | ||
|---|---|---|---|
| Name | Degree | Name | Degree |
| FN1 | 40 | TP53 | 42 |
| COL1A1 | 37 | TLR3 | 22 |
| COL3A1 | 36 | MYD88 | 20 |
| COL1A2 | 34 | SMAD3 | 19 |
| FBN1 | 29 | ISG15 | 19 |
| BGN | 28 | HSP90AA1 | 19 |
| COL5A2 | 28 | TRAF6 | 19 |
| THBS2 | 25 | IRF7 | 18 |
| COL5A1 | 25 | ATP4A | 16 |
| SPARC | 24 | TBK1 | 16 |
| COL6A3 | 22 | KEAP1 | 16 |
| COL11A1 | 21 | SHH | 16 |
| SPP1 | 21 | RIPK1 | 16 |
| COL12A1 | 20 | GAST | 15 |
| TIMP1 | 20 | NEDD4L | 15 |
| VCAN | 20 | UBE2D3 | 14 |
| CDH11 | 19 | TAB2 | 14 |
| SERPINH1 | 18 | CHGA | 13 |
| COL4A2 | 18 | ALDH1A1 | 13 |
| ASPN | 15 | GNB1 | 13 |
| BMP1 | 14 | SST | 13 |
| APOE | 14 | RSAD2 | 13 |
| NID2 | 13 | MX1 | 13 |
| COL10A1 | 13 | IFIT3 | 13 |
| COL8A1 | 12 | MAP3K7 | 13 |
| IGFBP7 | 11 | NQO1 | 12 |
| ADAMTS2 | 11 | HMOX1 | 12 |
| FAP | 10 | MX2 | 12 |
| THY1 | 10 | IFIT2 | 12 |
| LGALS1 | 10 | OASL | 12 |