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. 2020 Jul 16;12:224. doi: 10.3389/fnagi.2020.00224

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Copyright © 2020 Uryash, Flores, Adams, Allen and Lopez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of dantrolene on calpain activity and cell viability in aged hippocampal neurons. Calpain activity was higher in middle-aged and aged hippocampal neurons than young neurons (A), and these differences were accompanied by a decreased cell viability in middle-aged and aged hippocampal neurons compared to young neurons (B). Dantrolene (20 μM) reduced calpain activity, and increased cell viability in aged hippocampal neurons. On the horizontal axis are indicated the experimental conditions. For calpain: n_mice = 3/age group; for cell viability: n_mice = 4/per age group. Values are expressed as means ± S.D. for each condition. One-way ANOVA followed by Tukey’s post hoc comparisons, *p ≤ 0.05; NS, not significant.