Figure 2.

ZY0511 and 5-FU combination synergistically inhibits CRC cells proliferation in vitro (A) The proliferation of human CRC cells was evaluated by MTT assay after various concentrations of ZY0511 treatment for 48 and 72 h, respectively. The IC50 values were the mean of three individual experiments. (B) Cells were treated with ZY0511 in combination with 5-FU in CRC cells. Percentages of growth inhibition at each concentration of the drugs are presented. Data are show as mean of three independent experiments. (C) CI scores for CRC cells treated with 5-FU in combination with ZY0511 at the indicated concentrations. Each CI score represents data from three independent experiments.

CI, combination index; CRC, colorectal cancer; 5-FU, 5-fluorouracil; MTT, 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide.