Figure 5.
ZY0511 in combination with 5-FU inhibits CRC growth in vivo (A) Representative images of tumor for SW620 and DLD1 xenografts treated with vehicle, 5-FU (30 mg/kg) and/or ZY0511 (50 mg/kg), respectively. (B–C) Mean tumor volume (mm3) (left), tumor weights (middle) and body weights (right) of SW620 (B) and DLD1 (C) xenografts during treatment with 5-FU and/or ZY0511. Data are shown as mean ± SD. (n = 6 per group). (D) Representative images of live (top) and lung (bottom) metastasis nodules for SW620 metastasis model treated with vehicle, 5-FU (30 mg/kg) and/or ZY0511 (50 mg/kg), respectively. (E–F) Numbers of lung (E) and liver (F) metastasis nodules are shown as mean ± SEM (n = 6 per group). (G–H) Representative images of Ki-67 and cleaved-caspase3 in SW620 (G) and DLD1 (H) xenograft tumor samples.
*p < 0.05, **p < 0.01. Scale bar represents a distance of 50 μm.
5-FU, 5-fluorouracil; SD, standard deviation; SEM, standard error of the mean.