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. Author manuscript; available in PMC: 2020 Jul 24.
Published in final edited form as: J Med Chem. 2019 May 24;62(11):5330–5357. doi: 10.1021/acs.jmedchem.8b01709

Scheme 5. Synthesis of Target Compounds 48–105a.

Scheme 5.

aReagents and conditions: (a) synthesized or commercial benzaldehydes, NH4OAc, toluene, reflux, 4–12 h; (b) appropriately substituted commercially obtained amines or synthesized amines 43, 47 and 43a HCTU, HOBt, EtN(i-Pr)2, DCM, 0°C to rt, overnight.