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. Author manuscript; available in PMC: 2020 Jul 24.
Published in final edited form as: J Med Chem. 2019 May 24;62(11):5330–5357. doi: 10.1021/acs.jmedchem.8b01709

Figure 2.

Figure 2.

Figure 2.

(A) Design strategy for sequential optimization of high nanomolar inhibitory lead 60. (B) Favorable and unfavorable substitutions outlined for the four phases of SAR (Linkers in the structures are abbreviated as ‘L’).