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. Author manuscript; available in PMC: 2020 Jul 24.
Published in final edited form as: J Med Chem. 2019 May 24;62(11):5330–5357. doi: 10.1021/acs.jmedchem.8b01709

Scheme 3. Synthesis of Benzaldehyde Intermediates 29–41a.

Scheme 3.

aReagents and conditions: (a) 4-formylbenzoic acid or 3-formylbenzoic acid, appropriate (un) substituted THTP or benzimidazole-2-yl-ethylamine, HCTU, HOBt, EtN(i-Pr)2, DCM, 0°C to rt, overnight.