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. Author manuscript; available in PMC: 2021 Jan 1.

Published in final edited form as: Clin Pharmacol Ther. 2019 Dec 11;107(1):186–194. doi: 10.1002/cpt.1684

Figure 2. — Summary of internal validation of the morphine population models.

Panels A, present the model predicted morphine clearance estimates (in L/h) as a function of gestational age from 30 to 40 weeks; Panel B, present the model predicted morphine clearance estimates (in L/h) as a function of age from zero to 3 years of age; Panel C, present the model predicted morphine clearance estimates (in mL/min) for each of the nine case examples: a 32 week preterm neonate (PT1D), a 32 week preterm neonates (PT2W), a 38 week term neonate (FT1D), a 40 week term neonate (FT2W), a 3 month old infant born term (IN3M), a 6 month old infant (IN6M), and a one year old infant (IN1Y), a 2 year old infant (IN2Y), and a 3 year old infant (IN3Y).

Patient weight was derived using gestational age (Panel A: data from https://www.momjunction.com/articles/baby-weight-gain-and-weight-chart_00362524/#gref) or the post-natal age (Panel B: standard growth curve).

Figure 2. — Summary of internal validation of the morphine population models.

Panels A, present the model predicted morphine clearance estimates (in L/h) as a function of gestational age from 30 to 40 weeks; Panel B, present the model predicted morphine clearance estimates (in L/h) as a function of age from zero to 3 years of age; Panel C, present the model predicted morphine clearance estimates (in mL/min) for each of the nine case examples: a 32 week preterm neonate (PT1D), a 32 week preterm neonates (PT2W), a 38 week term neonate (FT1D), a 40 week term neonate (FT2W), a 3 month old infant born term (IN3M), a 6 month old infant (IN6M), and a one year old infant (IN1Y), a 2 year old infant (IN2Y), and a 3 year old infant (IN3Y).

Patient weight was derived using gestational age (Panel A: data from https://www.momjunction.com/articles/baby-weight-gain-and-weight-chart_00362524/#gref) or the post-natal age (Panel B: standard growth curve).