Fig. 3. Possible working mechanism of circRNAs as miRNA suppressors. (A) Analysis of circRNAs as miRNA suppressors. Among the increased miRNAs in patients with Kawasaki disease, miRNAs with predicted binding sites in circRNA sequences were selected using TargetScan.¹⁹ (B-C) The miRNA binding sites in circRNAs are depicted for (B) circWHAMMP1 and (C) circZNF124. (D) Base pairing between the predicted miRNA binding sites and circRNAs is shown. The nucleotide position of the back-splice junction depicted in (B, C) was set as zero, and the relative position of the nucleotide sequences was calculated.

circRNA, circular RNA; miRNA, microRNA.