Fig. 4. Adenoviral overexpression of Sptlc2 improved glucose tolerance, pyruvate tolerance, and insulin intolerance. Mice fed regular chow were infected with AdGFP or AdSptlc2 via a tail-vein injection (1×10⁹ PFU). After 2 weeks, a GTT (A), PTT (B), and ITT (C) were performed. At various time points, blood was collected, and the glucose levels in the blood were measured, as described in the Materials and Methods section. Mean±standard error of the mean.

AdGFP, adenovirus containing green fluorescent protein; AdSptlc2, adenovirus containing Sptlc2; GTT, glucose tolerance test; PTT, pyruvate tolerance test; ITT, insulin tolerance test.

^*p<0.05 vs. green fluorescent protein control (n=5).