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. 2020 Jul 17;8:632. doi: 10.3389/fcell.2020.00632

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Copyright © 2020 Bernstein and Rom.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Let-7 miRs differentially reduce cytokine release following stroke. ELISA analysis of IP-10 (A), CCL2 (B), CCL3 (C), CCL5 (D), CXCL2 (E), and KC/GRO (CXCL-1 mouse analog) (F) expression. Mice were subjected to 60 min ischemia and 72 h reperfusion performed as described in section “Materials and Methods.” Brains were harvested following anesthesia, homogenized, and were used to run all assays. Results are presented as mean ± SD from at least two independent experiments (n = 4). #p < 0.05 (SCRM); *p < 0.05 (let-7g*, miR-98). ##p < 0.01 (SCRM); ns is not significant.