Content	Strength of recommendation	Level of evidence
1	Patients with CVD (CAD, peripheral artery disease, atherosclerotic ischemic stroke, transient ischemic attack) are classified as a very high-risk group, and the treatment goal is to lower LDL-C levels to <70 mg/dL or by >50% from the baseline level for secondary prevention.	I	A
2	If acute myocardial infarction occurs, administer statins immediately regardless of the baseline LDL-C level.	I	A
3	Patients with carotid disease (significant carotid artery stenosis), abdominal aortic aneurysm, or diabetes are classified as a high-risk group. For this group, begin treatment when LDL-C concentration is ≥100 mg/dL for primary prevention.	I	A
4	Patients with two or more major risk factors other than LDL-C are classified as a moderate-risk group. For this group, administer statin if LDL-C concentration is ≥130 mg/dL even after weeks or months of lifestyle adjustment.	II	B
5	Patients with one or fewer major risk factors other than LDL-C are classified as low-risk group. For this group, administer statin if LDL-C concentration ≥160 mg/dL even after weeks or months of lifestyle adjustment.	II	B
6	If LDL-C concentration is ≥190 mg/dL, check whether the patient has other causes for hyperlipidemia, such as biliary obstruction, nephrotic syndrome, hypothyroidism, pregnancy, use of glucocorticoids or cyclosporine and make necessary adjustments.	I	B
7	If LDL-C concentration is ≥190 mg/dL in absence of secondary causes, begin statin administration regardless of the risk.	I	A
8	If blood triglyceride concentration rises to ≥500 mg/dL, check for secondary causes of triglyceride elevation, such as weight gain, drinking, carbohydrate intake, chronic kidney disease, diabetes, hypothyroidism, pregnancy, and use of estrogen, tamoxifen, or glucocorticoids and for other genetic problems that may cause abnormal lipid metabolism.	I	A
9	If triglyceride concentration is consistently ≥500 mg/dL, drug therapy, such as fibrate and omega-3 fatty acid therapy, may be initiated to prevent pancreatitis.	II	A
10	If triglyceride concentration is between 200–499 mg/dL with high LDL-C level, it is recommended to begin statin administration to primarily lower LDL-C concentration to the targeted level.	I	A
11	If hypertriglyceridemia persists (≥200 mg/dL) even after lifestyle adjustment and statin administration in very high-risk and high-risk patients, drugs that lower triglyceride levels, such as fibrate or omega-3 fatty acids, may be additionally used to prevent CVD.	II	B