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. 2019 Aug 7;8(2):78–131. doi: 10.12997/jla.2019.8.2.78
Content Strength of recommendation Level of evidence
1 The primary goal of dyslipidemia treatment is to lower LDL-C. I A
2 Non-HDL-C can be controlled as a secondary goal after achieving the targeted LDL-C concentration. II A
3 Appropriate statin administration should be considered for high-risk and very high-risk groups in order to meet the LDL-C target. IIa B
4 Statin should be considered to use for low-risk or moderate-risk groups when LDL-C level is not reduced to the target even after weeks and months of lifestyle modification. IIa B
5 Ezetimibe or bile acid sequestrants should be considered for patients with statin intolerance. IIa B
6 Combination with ezetimibe should be considered if LDL-C target is not achieved even after using maximum tolerable dose of statin IIa B
7 PCSK9 inhibitors may be considered to concurrent use for the very high-risk group if LDL-C target is not achieved even after using maximum tolerable dose of statin alone or with ezetimibe. IIb A
8 Bile acid sequestrants may be considered if LDL-C target is not achieved even after administering statin. IIb C
9 Combination of statin and nicotinic acid is not recommended to achieve the LDL-C target. III A
10 If the targeted level is not achieved even after using statin alone or with other agents in the very high-risk group, reducing LDL-C by 50% of the baseline concentration is recommended. I A
11 Administer statin immediately for patients with acute myocardial infarction regardless of the baseline LDL-C concentration. I A
12 For individuals with a triglyceride concentration of 500 mg/dL or higher, immediate drug therapy and lifestyle modification are important to prevent acute pancreatitis. I A
13 For individuals with a triglyceride concentration of 200–499 mg/dL, the primary treatment goal is to lower the LDL-C to the targeted level based on the calculated cardiovascular risk. I A
14 For individuals with a triglyceride concentration of 200–499 mg/dL, pharmacological therapy should be considered to lower triglyceride concentration after achieving the targeted LDL-C level if triglyceride concentration is >200 mg/dL with cardiovascular risk factors, or if non-HDL-C concentration is above the target. IIa B
15 If indicated, fibrates should be used to control triglyceride concentration. I B
16 If indicated, omega-3 fatty acids should be considered to control triglyceride concentration. IIa B
17 Combination drug therapy may be considered if targeted triglyceride level is not met after monotherapy. IIb C
18 The primary goal for low HDL cholesterolemia treatment is to control LDL-C to below the target. I A