|
Content |
Strength of recommendation |
Level of evidence |
1 |
The primary goal of dyslipidemia treatment is to lower LDL-C. |
I |
A |
2 |
Non-HDL-C can be controlled as a secondary goal after achieving the targeted LDL-C concentration. |
II |
A |
3 |
Appropriate statin administration should be considered for high-risk and very high-risk groups in order to meet the LDL-C target. |
IIa |
B |
4 |
Statin should be considered to use for low-risk or moderate-risk groups when LDL-C level is not reduced to the target even after weeks and months of lifestyle modification. |
IIa |
B |
5 |
Ezetimibe or bile acid sequestrants should be considered for patients with statin intolerance. |
IIa |
B |
6 |
Combination with ezetimibe should be considered if LDL-C target is not achieved even after using maximum tolerable dose of statin |
IIa |
B |
7 |
PCSK9 inhibitors may be considered to concurrent use for the very high-risk group if LDL-C target is not achieved even after using maximum tolerable dose of statin alone or with ezetimibe. |
IIb |
A |
8 |
Bile acid sequestrants may be considered if LDL-C target is not achieved even after administering statin. |
IIb |
C |
9 |
Combination of statin and nicotinic acid is not recommended to achieve the LDL-C target. |
III |
A |
10 |
If the targeted level is not achieved even after using statin alone or with other agents in the very high-risk group, reducing LDL-C by 50% of the baseline concentration is recommended. |
I |
A |
11 |
Administer statin immediately for patients with acute myocardial infarction regardless of the baseline LDL-C concentration. |
I |
A |
12 |
For individuals with a triglyceride concentration of 500 mg/dL or higher, immediate drug therapy and lifestyle modification are important to prevent acute pancreatitis. |
I |
A |
13 |
For individuals with a triglyceride concentration of 200–499 mg/dL, the primary treatment goal is to lower the LDL-C to the targeted level based on the calculated cardiovascular risk. |
I |
A |
14 |
For individuals with a triglyceride concentration of 200–499 mg/dL, pharmacological therapy should be considered to lower triglyceride concentration after achieving the targeted LDL-C level if triglyceride concentration is >200 mg/dL with cardiovascular risk factors, or if non-HDL-C concentration is above the target. |
IIa |
B |
15 |
If indicated, fibrates should be used to control triglyceride concentration. |
I |
B |
16 |
If indicated, omega-3 fatty acids should be considered to control triglyceride concentration. |
IIa |
B |
17 |
Combination drug therapy may be considered if targeted triglyceride level is not met after monotherapy. |
IIb |
C |
18 |
The primary goal for low HDL cholesterolemia treatment is to control LDL-C to below the target. |
I |
A |