Fibrate |
Usage/dosage |
Bezafibrate: 400–600 mg/day, 1–3 times a day, after meals |
Fenofibrate: 160–200 mg/day, once a day, immediately after meals |
Gemfibrozil: 600–1,200 mg/day, twice a day, 30 minutes before meals (avoid combination therapy with statin) |
Follow-up test |
Lipid profile, liver function test, general blood test, CK (when there is unexplainable muscle pain or muscle weakness) |
Adverse reaction |
Indigestion, cholesterol gallstones, myopathy |
Contraindications |
Severe liver disease, gallbladder disease, and hypersensitivity to fibrate is absolute contraindications, and use of the drug requires precaution for individuals with reduced kidney function |