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. 2018 Dec 18;286(1):8–23. doi: 10.1111/febs.14712

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© 2018 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) Gene expression of SQSTM1/p62 through stress‐responsible transcription factors. CLEAR: coordinated lysosomal expression regulation. ARE: antioxidant response element. (B) Domain structure of the p62 protein. Through the interaction with multiple proteins, p62 serves as a signaling hub that modulates a variety of cellular functions (anabolism and catabolism) and/or protein property (phase separation), which are regulated by post‐translational modifications of p62. PB1: Phox and Bem1p. ZZ: Zinc finger. NLS: nuclear localization signal. TB: TRAF6‐binding domain. NES: nuclear export signal. LIR: LC3‐interacting region. KIR: Keap1‐interacting region. UBA: ubiquitin‐associated.