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. 2020 Jun 2;64(13):2000063. doi: 10.1002/mnfr.202000063

Figure 6.

Figure 6

Predicted BMDL10‐BMDU10 values for acute liver toxicity of AFB1 in male rat obtained by the PBK modeling‐facilitated reverse dosimetry approach using data from fresh hepatocytes by Zhang et al.[ 54 ] and Hanigan and Laishes[ 55 ] (white rectangle bars). The predicted BMDL10‐BMDU10 are compared to POD for ALT or AST response after a single exposure (striped rectangle bars) or repeated exposure (striped gray rectangle bars) and in vivo male median lethal doses (LD50) (gray rectangle bars). PO = oral, ALT = aminotransferase, and AST = aspartate aminotransferase.