Figure 1.
Cardiac myofilament function in a mouse model of peri‐menopause. A, Cardiac actomyosin MgATPase activity was measured across a range of free calcium concentrations. Maximum activity increased at day 60 post‐VCD treatment as compared to intact mice. B, At day 120 post‐VCD treatment EC50 was significantly higher in VCD‐treated mice as compared to intact controls. C, Hill coefficient was not affected at either VCD timepoint. Note: VCD 60 D, 60 days after VCD injections; VCD 120 D, 120 days after VCD injections. N = 7 in each group. *P < 0.05 vs intact control