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. 2019 May 31;227(1):e13290. doi: 10.1111/apha.13290

Figure 5.

Figure 5

Peri‐menopause impairs control of left ventricular contractility by acute oestrogen receptor activation. Mice were injected with VCD daily for 15 days to induce ovarian failure. 60 days after injections ovarian function is disrupted. Oestrogen receptor‐α (PPT, 100 nM) activation produced a transient decrease in left ventricular systolic pressure and rate of contraction (dP/dt max) that was lost by 15 min of treatment. Oestrogen receptor‐β (DPN, 1 nM) activation did not significantly impact any functional parameter in mice 60 days post‐VCD treatment. Note: LVESP, left ventricular end‐systolic pressure; LVDP, left ventricular developed pressure; dP/dt max, maximum rate of ventricular contraction; dP/dt min, maximum rate of ventricular relaxation; VCD 60 D, 60 days after VCD injections. N = 7 in each treatment group. *P < 0.05 vs VCD 60 days control at same timepoint