Table 1.
Animal characteristics prior to and directly after trauma
| No transfusion | Standard products | Optimized products | ||||
|---|---|---|---|---|---|---|
| Baseline | Hypovolemic shock* | Baseline | Hypovolemic shock* | Baseline | Hypovolemic shock* | |
| Clinical parameters | ||||||
| Weight (g) | 404.0 (401.5–405.5) | 406.0 (398.0–416.0) | 395.0 (393.3–401.3)† ‡ | |||
| Chemical lab | ||||||
| Hemoglobin level (mmol/L) | 10.1 (8.5–11.7) | 9.1 (7.6–10.7) | 9.1 (7.8–9.7) | 9.9 (9.3–10.1) | 9.4 (8.6–10.0) | 9.2 (8.3–9.8) |
| Hematocrit (%) | NR | 0.39 (0.36–0.42) | 0.47 (0.31–0.56) | 0.50 (0.38–0.56) | 0.52 (0.49–0.64) | 0.56 (0.51–0.62) |
| Creatinine (μmol/L) | 30.5 (26.0–35.0) | 37.0 (33.0–64.0) | 24.0 (20.0–26.0)† | 34.0 (30.0–62.0)§ | 28.5 (26.3–39.8)‡ | 42.0 (35.5–51.5)§ |
| AST (U/L) | 51 (51–51) | 61 (48–97) | 56 (53–79) | 110 (94–113)§ | 73 (57–98) | 105 (89–122) |
| ALT (U/L) | 37 (35–39) | 36 (36–76) | 46 (38–54) | 84 (67–89)§ | 53 (52–63) | 84 (69–114)§ |
| LDH (mmol/L) | 80 (80–80) | 221 (137–430) | 237 (172–301) | 505 (393–641)§ | 316 (188–499) | 513 (425–728) |
| Blood gas | ||||||
| pH | 7.42 (7.20–7.47) | 7.40 (7.01–7.43) | 7.28 (7.24–7.38) | 7.36 (7.13–7.45) | 7.47 (7.39–7.52) | 7.36 (7.23–7.39) |
| pCO2 (mm Hg) | 38.2 (14.0–57.1) | 36.9 (22.4–104.3) | 44.6 (31.9–64.1) | 35.7 (37.7–70.4) | 30.9 (24.0–42.9) | 40.2 (32.2–52.9) |
| HCO3 – (mmol/L) | 21.9 (10.1–24.9) | 20.5 (14.4–24.7) | 21.4 (17.8–27.6) | 21.2 (18.8–22.5) | 22.4 (18.7–25.6) | 21.9 (18.1–23.5) |
| BD (mmol/L) | −6.7 (−13.2 – −0.6) | −10.3 (−12.1 – −2.6) | −4.4 (−6.8 – −2.6) | −3.3 (−7.6 – −1.8) | −1.2 (−2.6–0.8)‡ | −2.6 (−6.8 – −2.2)§ |
| Lactate (mmol/L) | 1.06 (0.21–1.14) | 1.74 (1.06–5.19) | 0.50 (0.31–0.58) | 1.11 (0.89–1.64)§ | 0.78 (0.74–1.04) | 1.33 (1.07–1.93)§ |
| Hemodynamics | ||||||
| MAP (mm Hg) | 105 (69–130) | 48 (38–53)§ | 125 (98–136) | 50 (41–67)§ | 120 (114–128) | 50 (41–51)§ |
Values are expressed as median and IQR.
*
Values are recorded after trauma and hemorrhage, just after transfusion therapy was given in the resuscitation groups.
†
p < 0.05 versus no transfusion group.
‡
p < 0.05 versus standard transfusion group.
§
p < 0.05 versus baseline value in same group.
ALT = alanine transaminase; AST = aspartate transaminase; BD = base deficit; LDH = lactic dehydrogenase; MAP = mean arterial pressure; NR = not recorded.