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. 2020 Jul 17;11:1065. doi: 10.3389/fphar.2020.01065

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Copyright © 2020 Xing, Fu, Cheng, Cai, Wang, Deng, Gong and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A schematic illustrating the mechanisms involved in the protection of hyperoside against oxidative liver stress. Hyperoside was able to down regulate PHLPP2 expression in liver cells treated with t-BHP and in CCl4-injured rat liver to induce AKT phosphorylation and inactivate GSK-3β (Ser9), and thereby, reduced Fyn phosphorylation, and nuclear translocation. The phosphorylation of Nrf2 at S40 site was probably involved in Hyp-mediated regulation of Fyn kinase, likely through nuclear translocation for HO-1 transcription and translation. The dashed line highlights that this is a strong suggestion and has not been completely proven with experiment.