Table 5.
Multivariant Cox regression analysis of OS and PFS in OC patients.
| Variables | ITGA3 | ITGA6 | ITGB4 | ITGB8 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value | |
| A.OS | ||||||||||||
| Age (<60/≥60) |
1.333 | 1.0240–1.7352 | 0.032 | 1.3028 | 0.9972–1.7022 | 0.0525 | 1.3578 | 1.0429–1.7676 | 0.0231 | 1.3819 | 1.0597–1.8021 | 0.01693 |
| Stage (I+II/III+IV) |
2.1172 | 0.9329–4.8045 | 0.0728 | 1.8666 | 0.8231–4.2330 | 0.1352 | 2.0041 | 0.8846–4.5407 | 0.0957 | 2.1571 | 0.9475–4.9113 | 0.06704 |
| Chemotherapy (NO/YES) | 0.3846 | 0.2442–0.6058 | 3.74E-05 | 0.3596 | 0.2287–0.5655 | 9.51E-06 | 0.3732 | 0.2375–0.5864 | 1.92E-05 | 0.3942 | 0.2494–0.6229 | 6.68E-05 |
| Hormonetherapy (NO/YES) | 1.0106 | 0.6712–1.5217 | 0.9596 | 0.9792 | 0.6504–1.4743 | 0.92 | 1.0144 | 0.6737–1.5275 | 0.9453 | 1.0247 | 0.6809–1.5421 | 0.90683 |
| Immunotherapy (NO/YES) | 0.8538 | 0.3736–1.9514 | 0.7078 | 0.8208 | 0.3587–1.8782 | 0.6402 | 0.8324 | 0.3643–1.9021 | 0.6635 | 0.8694 | 0.3804–1.9868 | 0.73994 |
| Targettherapy (NO/YES) | 0.6727 | 0.4072–1.1114 | 0.1217 | 0.7017 | 0.4253–1.1579 | 0.1656 | 0.6868 | 0.4160–1.1337 | 0.1418 | 0.7335 | 0.4448–1.2095 | 0.2245 |
| Indicated Gene (Low/High) | 1.4733 | 1.0964–1.9797 | 0.0102 | 0.8145 | 0.6001–1.1056 | 0.1882 | 1.4038 | 1.0462–1.8837 | 0.0238 | 1.5314 | 1.1440–2.0499 | 0.00418 |
| B.PFS | ||||||||||||
| Age (<60/≥60) |
1.167 | 0.9191–1.483 | 0.2047 | 1.1582 | 0.9095–1.475 | 0.2337 | 1.2134 | 0.9546–1.542 | 0.114 | 1.1842 | 0.9328–1.503 | 0.16494 |
| Stage (I+II/III+IV) |
1.674 | 0.9293–3.0160 | 0.0862 | 1.5833 | 0.8783–2.854 | 0.1264 | 1.7056 | 0.9487–3.067 | 0.0744 | 1.7396 | 0.9650–3.136 | 0.06555 |
| Chemotherapy (NO/YES) | 0.667 | 0.4320–1.030 | 0.0676 | 0.652 | 0.4221–1.007 | 0.0538 | 0.7154 | 0.4613–1.109 | 0.1346 | 0.7299 | 0.4699–1.134 | 0.16125 |
| Hormonetherapy (NO/YES) | 1.047 | 0.7240–1.515 | 0.8056 | 1.0348 | 0.7150–1.498 | 0.856 | 1.0166 | 0.7024–1.471 | 0.9305 | 1.0423 | 0.7202–1.508 | 0.82596 |
| Immunotherapy (NO/YES) | 1.109 | 0.5637–2.182 | 0.7644 | 1.0937 | 0.5563–2.150 | 0.795 | 1.1132 | 0.5664–2.188 | 0.7557 | 0.9874 | 0.4996–1.952 | 0.97098 |
| Targettherapy (NO/YES) | 1.044 | 0.6825–1.598 | 0.8414 | 1.058 | 0.6915–1.619 | 0.7951 | 0.9993 | 0.6518–1.532 | 0.9975 | 1.1014 | 0.7193–1.687 | 0.65678 |
| Indicated Gene (Low/High) | 1.191 | 0.9102–1.559 | 0.2026 | 0.8831 | 0.6949–1.122 | 0.3095 | 1.3724 | 1.0777–1.748 | 0.0103 | 1.4117 | 1.1048–1.804 | 0.00583 |
Bold font indicates significant difference.