Table 2.
DHS and spherocytosis in comparison
| DHS | Spherocytosis | |
|---|---|---|
| MCHC | Increased | Increased |
| RDW | Increased | Increased |
| MCV | Tendency to macrocytosis | Normal or slightly reduced |
| Peripheral blood smear | Stomatocytes | Spherocytes |
| Splenomegaly | mild / moderate | Variable from mild to severe |
| EMA test and RBCs lysis tests | Normal/Increased | Decreased |
| Ectacytometry | Normal EImax and left shift of Omin and OHyper due to the presence of dehydrated red cells. | Reduction of EImax, shift to the right of Omin point (reduced surface / volume ratio) and shift to the left of Ohyper point (increased dehydration of the red cells). |
| Causative genes | PIEZO1/ KCNN4 | ANK1/ SPTB/ SPTA1/ SLC4A1/ EPB42 |