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. 2020 Jul 17;10:1034. doi: 10.3389/fonc.2020.01034

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Copyright © 2020 Shi, Li, Feng, Liu, Feng and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-125b-5p is negatively associated with colon cancer and cisplatin resistance. (A) Quantitative RT-PCR results of the miR-125b-5p expressions in 35 normal colon tissues and 35 tumor tissues (B) Quantitative RT-PCR results of the miR-125b-5p expressions in normal colon epithelial cell and five colon cancer cells. (C) Expressions of miR-125b-5p were detected from SW480 parental and cisplatin-resistant cells by qRT-PCT. (D) Cisplatin-resistant SW480 cells were transfected with control miR or miR-125b-5p, followed by cisplatin treatments at the indicated concentrations. Cell viability was measured by MTT assay. Data are presented as mean ± SD. *p < 0.05, **p < 0.01, and ***p < 0.001.