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. 2020 Jul 17;8:559. doi: 10.3389/fcell.2020.00559

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Copyright © 2020 Wang, Zheng, Pan, Yao, Gao, Wang and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Renal function in STZ-induced diabetic rats before administration. Four weeks after STZ administration, diabetic nephropathy models were examined based on general indicators. (A) Weight loss. (B) Food intake. (C) Water intake. (D) Blood glucose. (E) Blood pressure. (F) 24 h urine volume, (G) 24 h proteinuria, (H) Blood urea nitrogen (BUN), (I) Serum creatinine (Src), and (J) Urine creatinine (Ucr) were measured by ELISA. (K) Creatinine clearance rate. Data are expressed as mean ± SD. *p < 0.05, **p < 0.01, compared with the normal group.